ACR Imaging Network (ACRIN) Legacy Trials

The ACRIN® legacy protocols and associated case report forms are available below as a reference and for data access requests for ancillary research projects.

Researchers interested in accessing data from the ACRIN legacy trials should submit requests via the ECOG-ACRIN Data Access Committee.

ACRIN Protocol 6659

MR Imaging and MR Spectroscopic Imaging of Prostate Cancer Prior to Radical Prostatectomy: A Prospective Multi-Institutional Clinicopathological Study

• Protocol
• Case Report Forms

ACRIN Protocol 6664

The National CT Colonography Trial

• Protocol
• Case Report Forms

ACRIN Protocol 6665/RTOG Protocol 0132

Phase II Trial of Neoadjuvant/Adjuvant STI-571 (Gleevec NSC 716051) for Primary and Recurrent Operable Malignant Gastrointestinal Stromal Tumors Expressing the KIT Receptor Tyrosine Kinase (CD117)

• Protocol
• Case Report Forms

ACRIN Protocol 6673

Multicenter Feasibility Study of Percutaneous Radiofrequency Ablation of Hepatocellular Carcinoma in Cirrhotic Patients

• Protocol
• Case Report Forms

ACRIN Protocol 6687

A Phase 2, Multicenter Evaluation of 18F-Fluoride PET as a Pharmacodynamic Biomarker for Dasatinib, a Src Kinase Inhibitor, in Men With Castration-Resistant Prostate Cancer and Bone Metastases (BMS #180-279)

• Protocol
• Case Report Forms

ACRIN Protocol 6690

A Prospective, Multicenter Comparison of Multiphase Contrast-Enhanced CT and Multiphase Contrast-Enhanced MRI for Diagnosis of Hepatocellular Carcinoma and Liver Transplant Allocation

• Protocol
• Case Report Forms

ACRIN Protocol 6652

Digital Versus Film-Screen Mammography (DMIST)

• Protocol
• Case Report Forms

ACRIN Protocol 6657/CALGB 150007

Contrast-Enhanced Breast MRI for Evaluation of Patients Undergoing Neoadjuvant Treatment for Locally Advanced Breast Cancer

• Protocol
• Case Report Forms

ACRIN Protocol 6666

Screening Breast Ultrasound in High-Risk Women

• Protocol
• Case Report Forms

ACRIN Protocol 6667

MRI Evaluation of the Contralateral Breast in Women With a Recent Diagnosis of Breast Cancer

• Protocol
• Case Report Forms

ACRIN Protocol 6688

Phase II Study of 3'-Deoxy-3'-18F Fluorothymidine (FLT) in Invasive Breast Cancer

• Protocol
• Case Report Forms

ACRIN Protocol 6691

Monitoring and Predicting Breast Cancer Neoadjuvant Chemotherapy Response Using Diffuse Optical Spectroscopic Imaging (DOSI)

• Protocol
• Case Report Forms

ACRIN Protocol 6698

Diffusion Weighted MR Imaging Biomarkers for Assessment of Breast Cancer Response to Neoadjuvant Treatment: A sub-study of the I-SPY 2 TRIAL (Investigation of Serial Studies to Predict Your Therapeutic Response with Imaging And moLecular Analysis)

• Protocol
• Case Report Forms

ACRIN Protocol 6702

A Multi-Center Study Evaluating the Utility of Diffusion Weighted Imaging for Detection and Diagnosis of Breast Cancer

• Protocol
• Case Report Forms

ACRIN Protocol 6651

Role of Radiology in the Pretreatment Evaluation of Invasive Cervical Cancer

• Protocol

GOG 0233/ ACRIN Protocol 6671

Utility of Preoperative FDG-PET/CT Prior to Primary Chemoradiation Therapy to Detect Retroperitoneal Lymph Node Metastasis in Patients With Locoregionally Advanced Carcinoma of the Cervix (IB2, IIA =4 CM, IIB-IVA) or Endometrium (Grade 3 Endometrioid Endometrial Carcinoma; Serous Papillary Carcinoma, Clear Cell Carcinoma, or Carcinosarcoma (Any Grade); and Grade 1 or 2 Endometrioid Endometrial Carcinoma With Cervical Stromal Involvement Overt in Clinical Examination or Confirmed by Endocervical Curettage)

• Protocol
• Case Report Forms: Cervical | Endometrial

ACRIN Protocol 6682

Phase II Trial of 64Cu-ATSM PET/CT in Cervical Cancer

• Protocol
• Case Report Forms

ACRIN Protocol 6695

Prognostic Perfusion CT in Gynecological Cancer: A Randomized Phase III Trial of Every-3-Weeks Paclitaxel versus Dose Dense Weekly Paclitaxel in Combination with Carboplatin With or Without Concurrent and Consolidation Bevacizumab in the Treatment of Primary Stage I, II, III, or IV Epithelial Ovarian, Peritoneal, or Fallopian Tube Cancer

• Protocol
• Case Report Forms

RTOG 0625/ACRIN Protocol 6677

Staging With MR Perfusion Imaging and MR Spectroscopy. ACRIN 6677 is conducted in collaboration with RTOG 0625: A Randomized Trial of Bevacizumab With Temozlomide in Recurrent Glioblastoma

• Protocol
• Case Report Forms

ACRIN Protocol 6684

Multicenter, Phase II Assessment of Tumor Hypoxia in Glioblastoma Using 18F-Fluoromisonidazole (FMISO) With PET and MRI

• Protocol
• Case Report Forms

ACRIN Protocol 6685

A Multicenter Trial of FDG-PET/CT Staging of Head and Neck Cancer and Iits Impact on the N0 Neck Surgical Treatment in Head and Neck Cancer Patients

• Protocol
• Case Report Forms

RTOG 0825/ ACRIN Protocol 6686

Phase III Double-Blind Placebo-Controlled Trial of Conventional Concurrent Chemoradiation and Adjuvant Temozolomide Plus Bevacizumab Versus Conventional Concurrent Chemoradiation and Adjuvant Temozolomide in Patients With Newly Diagnosed Glioblastoma

• Protocol
• Case Report Forms

ACRIN Protocol 6654

Contemporary Screening for the Detection of Lung Cancer

• Protocol
• Case Report Forms

RTOG Protocol 0234/ ACRIN Protocol 6668

Positron Emission Tomography Pre- and Post-treatment Assessment for Locally Advanced Non-small Cell Lung Carcinoma

• Protocol
• Case Report Forms

ACRIN Protocol 6678

FDG-PET/CT as a Predictive Marker of Tumor Response and Patient Outcome: Prospective Validation in Non-small Cell Lung Cancer

• Protocol
• Case Report Forms

RTOG Protocol 1106/ ACRIN Protocol 6697

Randomized Phase 2 Trial of Individualized Adaptive Radiotherapy Using During-treatment FDG-PET/CT and Modern Technology in Locally Advanced Non-small Cell Lung Cancer (NSCLC)

• Protocol
• Case Report Forms